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Serious dermatological reactionsincluding Stevens-Johnson syndromeSJSand toxic epidermal necrolysisTENhave been reported in both pediatric and adult patients treated with KEPPRAThe median time of onset is reported to be 14 to 17 daysbut cases have been reported at least four months after initiation of treatmentRecurrence of the serious skin reactions following rechallenge with KEPPRA has also been reportedKEPPRA should be discontinued at the first sign of a rashunless the rash is clearly not drug-relatedIf signs or symptoms suggest SJS/TENuse of this drug should not be resumed and alternative therapy should be considered.
The active substance in Keppralevetiracetamis an anti-epileptic medicineEpilepsy is caused by excessive electrical activity in the brainThe exact way in which levetiracetam works is still unclear but it seems to interfere with a protein called synaptic vesicle protein 2Awhich is found in the spaces between nerves and is involved in the release of chemical messengers from nerve cellsThis helps Keppra to stabilise electrical activity in the brain and prevent seizures.
Available data in children did not suggest impact on growth and pubertyHoweverlong term effects on learningintelligencegrowthendocrine functionpuberty and childbearing potential in children remain unknown.
Potential drug interactions between KEPPRA and other AEDscarbamazepinegabapentinlamotriginephenobarbitalphenytoinprimidone and valproatewere also assessed by evaluating the serum concentrations of levetiracetam and these AEDs during placebo-controlled clinical studiesThese data indicate that levetiracetam does not influence the plasma concentration of other AEDs and that these AEDs do not influence the pharmacokinetics of levetiracetam.
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generic for keppra levetiracetam is an anti-epileptic drug used to treat partial onset, tonic clonic, or myoclonic seizures in people with epilepsy.
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