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If nevirapine extended-release interrupted7 daysrestart with lead-in dosing with immediate-release nevirapine.
Risk of severelife threatening skin reactions including Stevens-Johnson syndrometoxic epidermal necrolysisand hypersensitivity.
Caution should be exercised when co-administering telaprevir with nevirapine.
Granulocytopenia is commonly associated with zidovudineThereforepatients who receive nevirapine and zidovudine concomitantly and especially paediatric patients and patients who receive higher zidovudine doses or patients with poor bone marrow reservein particular those with advanced HIV diseasehave an increased risk of granulocytopeniaIn such patients haematological parameters should be carefully monitored.
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