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When it first gained FDA approval in 1991Zofran came in the form of an injection for intravenousIVuseOver the yearsthe FDA has approved various oral forms of the drug.
Table 2Pediatric Recommended Dosage Regimen for Prevention of Nausea and Vomiting.
Ondansetron is extensively metabolized in humanswith approximately 5of a radiolabeled dose recovered as the parent compound from the urineThe metabolites are observed in the urineThe primary metabolic pathway is hydroxylation on the indole ring followed by subsequent glucuronide or sulfate conjugation.
Before taking ondansetrontell your doctor if you have liver diseaseor a personal or family history of Long QT syndrome.
Otherless than 2Anaphylaxisbronchospasmtachycardiaanginahypokalemiaelectrocardiographic alterationsvascular occlusive eventsand grand mal seizuresExcept for bronchospasm and anaphylaxisthe relationship to ZOFRAN is unclear.
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