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Clinical studies have demonstrated that elevated levels of total-CLDL-C and Apo Bthe major protein constituent of LDLpromote human atherosclerosisIn additiondecreased levels of HDL-C are associated with the development of atherosclerosisEpidemiologic studies have established that cardiovascular morbidity and mortality vary directly with the level of total-C and LDL-C and inversely with the level of HDL-CLike LDLcholesterol-enriched triglyceride-rich lipoproteinsincluding very-low-density lipoproteinsVLDLintermediate-density lipoproteinsIDLand remnantscan also promote atherosclerosisThe independent effect of raising HDL-C or lowering TG on the risk of coronary and cardiovascular morbidity and mortality has not been determined.
If ezetimibe is added to warfarina coumarin anticoagulantthe International Normalized RatioINRshould be appropriately monitored.
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