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Adverse reactions after discontinuation of serotonergic antidepressantsparticularly after abrupt discontinuationincludenauseasweatingdysphoric moodirritabilityagitationdizzinesssensory disturbancese.gparesthesiasuch as electric shock sensationstremoranxietyconfusionheadachelethargyemotional labilityinsomniahypomaniatinnitusand seizuresA gradual reduction in dosage rather than abrupt cessation is recommended whenever possibleSee DOSAGE AND ADMINISTRATION
It is unknown whether the risk of suicidal thoughts and behaviors in pediatric and young adult patients extends to longer-term usei.ebeyond four monthsHoweverthere is substantial evidence from placebo-controlled maintenance trials in adults with MDD that antidepressants delay the recurrence of depression.
No suicides occurred in any of the pediatric studiesThere were suicides in the adult studiesbut the number was not sufficient to reach any conclusion about antidepressant drug effect on suicide.
Adverse reactions may occur upon discontinuation of ZOLOFTSee WARNINGS AND PRECAUTIONSGradually reduce the dosage rather than stopping ZOLOFT abruptly whenever possible.
Anxietyirritabilityhigh or low moodfeeling restless or changes in sleep habits headachesweatingnauseadizziness electric shock-like sensationsshakingconfusion.
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